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KMID : 1034720120040010001
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Journal of Neurosonology and Neuroimaging
2012 Volume.4 No. 1 p.1 ~ p.7
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Current Status of Sonothrombolysis and its Future Future
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Kim Young-Dae
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Abstract
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Thrombolytic treatment with intravenous (IV) tissue plasminogen activator (t-PA) is a proven therapyin acute ischemic stroke patients. Successful recanalization is a strong determinant for favorableoutcome in patients who received thrombolytic treatments. In the last few decades, thrombolysiswith ultrasound has been tested whether this modality can improve the successful recanalizationrate or clinical outcomes. Three different ultrasound technologies including transcranial Doppler,transcranial color-coded sonography, and low-frequency ultrasound were used to increase thethrombolytic efficacy of IV t-PA. Because microbubbles can lower the amount of ultrasound energyneeded for acoustic cavitation, concomitant use of microbubbles with ultrasound has been also testedfor the presence of additional benefits in sonothrombolysis. This article reviews the present statusof sonothromboolysis in acute ischemic stroke and discusses its future.
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KEYWORD
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Stroke, Sonothrombolysis
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